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Chin Med J (Engl) (2021) 134(7):78391

If menopause increases inflammation and gut permeability, could BPC-157 act as a protective ally

Recent studies have shown that insulin-mediated suppression of hepatic gluconeogenesis occurs indirectly through the ability of insulin to suppress adipocyte lipolysis and the flux into liver pyruvate carboxylase, the rate-limiting enzyme in gluconeogenesis (183, 200)

This process establishes a chronic low-grade inflammatory state

In Pelizaeus-Merzbacher disease, a myelination defect, a subgroup of mutations affecting the extracellular loop of the PLP/DM20 protein impair formation of intramolecular disulfide bridges and cause abnormal protein cross-links, ER retention and oligodendrocyte death (Dhaunchak et al., 2005) and von Willebrand disease (Wang et al., 2012)