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In several reported pediatric cases, ingestion of large amounts of alpha-lipoic acid (for example, 2400 mg in a toddler) led to serious reactions such as seizures, loss of consciousness, or metabolic acidosis

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This finding reveals that heavy metal contamination not only causes tissue accumulation but also weakens the organisms homeostatic capacity by affecting the regulation of stress hormones

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Humans only produce alpha-lipoic acid in small amounts, but can take ALA via oral supplements or intravenously

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Nat Biotechnol 1990:8;27-32

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