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Kroemer, Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

PLoS One 10:e0138655 Semisch A, Hartwig A (2014) Copper ions interfere with the reduction of the water-soluble tetrazolium salt-8

Therefore, it is optimally used within 3-5 days

In 2026, research into its application for follicular rejuvenation has seen a massive resurgence as researchers look for alternatives to traditional androgen-focused treatments