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Central sensitization: iImplications for the diagnosis and treatment of pain

[online] Tsermpini, E.E., Plemenita Ilje, A

BMJ 374 , n1648 (2021)

Unlike the gold-standard Levodopa, which primarily alleviates symptoms but paradoxically generates iatrogenic ROS through auto-oxidation (Scigliano et al., 1997), bilirubin acts as an endogenous disease-modifying agent that specifically neutralizes such oxidative burdens (Jayanti et al., 2021)