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This can be achieved by using PD-1 blockade antibodies or modified CAR-T cells that secrete PD-1 blockade single-chain variable fragments (scFv) in PD-L1+ hematological and solid tumor clinically relevant syngeneic and xenograft mouse models (179), which can increase glucose concentration in TME to favor T cell glycolysis and the production of IFN- ( Figure 1 )

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Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur

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