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Rational drug design, which is the application of a structure-function relationship, is now widely used in modern medicinal chemistry for developing exquisitely selective ligands

376 The causal role of oxidative damage in the ageing process remains controversial, partly because of the absence of a clear correlation between the efficacy of antioxidant defenses and extended cellular function or longevity

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The complex structure was determined by molecular replacement (MR) with PHASER 63 using the crystal structures of the CHIKV prefusion E1E2 heterodimer (PDB ID 6JO8 28 ) and Fab (Alphafold2 generated) as search models

Phytother Res 39(9):42304246 Loya-Hernndez LP, Arzate-Quintana C, Castillo-Gonzlez AR, Camarillo-Cisneros J, Romo-Senz CI, Favila-Prez MA, Quionez-Flores CM (2025) Propolis-functionalized biomaterials for wound healing: a systematic review with emphasis on polysaccharide-based platforms