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For instance, amitriptyline, imipramine, and desipramine strongly inhibit 5-HT reuptake, 344 clomipramine specifically inhibits NE reuptake, and nortriptyline can inhibit both NE and 5-HT reuptake while also exerting central anticholinergic effects

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Folate Cycle As described, after conversion of SAMe to SAH in transmethylation reactions and obtention of Hcy by SAHH, the Hcy that does not flux towards the transsulfuration pathway must be remethylated to methionine, therefore closing the methionine cycle

CIII and CIV (together with CI) of the ETC act as H + pump and build up the membrane potential

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