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Natural products in drug discovery: advances and opportunities

In 1948, Rathbun first described the disease as hypophosphatasia in an infant, presented with severe bone loss, seizures, and low levels of alkaline phosphatase tissue and blood, who died of tonic epilepsy at 2 months of age [39]

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That being said, it may cause severe side effects if an allergy is present or if the individual is also taking certain medications

We've reviewed dozens of study protocols where washout periods were calculated based on plasma half-life alone, resulting in carryover effects that invalidated the entire crossover phase