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Methods for conjugation of nucleic acids and related oligomeric compounds with and without linking groups are well described in the literature such as, for example, in Manoharan in Antisense Research and Applications, Crooke and LeBleu, eds., CRC Press, Boca Raton, Fla., 1993, Chapter 17, which is incorporated herein by reference in its entirety

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SPR analysis of these interacting pairs determined binding affinity of 1.56 M for prothrombin 238.6 nM for collagen and 54.8 nM for fibrinogen, respectively (Supplementary Fig

10.1038/nature14344 Nature 69 JiangT.ChengH.SuJ.WangX.WangQ.ChuJ.et al (2020)