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However, present approaches of theoretical calculation are usually built upon TBC-based theories, showing huge limitations in accurately describing the electronic structure of aggregates and related noncovalent couplings

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In the CNS, they participate in increasing neuronal excitability and promote synaptic plasticity, which are key for learning and memory, through second messenger signaling pathways ( Figure 1 ) according to their pharmacology, sequence of amino acid homology, and signal transduction pathways ( 2+ from intracellular stores in the endoplasmic reticulum, and diacylglycerol activates protein kinase C ( + channels and inhibit voltage-gated Ca 2+ channels ( Figure 1

It also appears to decrease levels of the inflammatory marker interleukin-6 and has other anti-inflammatory effects

This stability supports its use across biochemical, cellular and preclinical experimental platforms