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Explain what happened then

Miyazawa, N

doi: 10.1080/03670240902794598

Toxic gain of function of mutSOD1 was suggested to perturb the activation of the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway[96], a major regulator of the phase II antioxidant response, including GPx, catalase, GR[6] and even SOD1[97]

853 However, in an 18-month-old patient with ethylmalonic encephalopathy, liver transplantation only partially improved symptoms and did not result in a complete cure, 854 suggesting that the procedure is most effective when performed before irreversible neurological damage occurs