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Statements Author contributions NG, DW, and PA drafted the manuscript and BP, NS, KS, DW, and PA helped in literature search and edited the manuscript

The theory holds that high lactic acid buildup makes IGF-1 receptors more receptive, so injecting into muscles about to be trained maximizes local effects

What's missing, and this matters: - As of 2026, no controlled trial has shown that ipamorelin actually improves body composition, sleep, or recovery over meaningful timeframes

Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study

hEPO mRNAs were synthesized in vitro using T7RNA polymerase-mediated DNA-dependent RNA transcription, where UTP was substituted with 100% N^methylpseudouracil (NIMPU), using a linearized template for each UTR combination