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The tRNA is initially aminoacylated with serine in a reaction catalysed by SerRS to form Ser-tRNA [Ser]Sec , which is the basis for Sec biosynthesis

Lukey et al , 2016), and loss of a single copy of Gls1 delays tumorigenesis in a mouse model of hepatocellular carcinoma (Xiang et al , 2015)

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No participants withdrew from any trial due to tolerability issues, indicating that even when side effects occurred, they were sufficiently manageable that participants chose to continue treatment

The reverse LC-MS/MS response curve ( y = 1.0088 x 0.014, R 2 = 0.9999) was linear in molar ratios between 0.043 and 8.65 with Y -axis being peak area ratio [ A ([ 15 N 13 ]-CNCbl)/ A (CNCbl)] and X -axis being the molar ratio [n([ 15 N 13 ]-CNCbl)/n(CNCbl)]