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Nevertheless, previous vaccine studies for SARS-CoV suggest that vaccine-induced antibodies may directly promote enhanced disease upon exposure to the virus via the activation of macrophages able to produce high levels of the chemokine CCL2 and the cytokine IL-8, resulting in lung injury 5

While established platforms like the MCP-MS2 system have successfully packaged PSA mRNA and circRNA for sustained antigen expression, the sensitivity of the protein-RNA assembly interface remains a primary bottleneck for industrial scale-up, necessitating rigorous, platform-specific empirical tuning (Gupta et al., 2024

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Furthermore, macrophages clear immune complexes produced by B cells via Fc receptors, preventing their deposition in the joint and reducing tissue damage (145)