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Weight loss through any interventionwhether pharmacological, surgical, or lifestyle-basedconsistently reduces inflammatory markers, making it difficult to isolate drug-specific effects

46 A randomized placebo-controlled trial in 29 postmenopausal women with fibromyalgia found 50 mcg of transdermal estradiol per day for eight weeks had no effect on pain and tenderness compared with placebo

doi:10.1016/j.drugalcdep.2005.09.002

And what's interesting in my younger years when I was teaching in Europe, I was having dinner with a German princess, and so you're kind of like wanting to be very formal at everything in a castle and all that

Ehrenreich, H