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167 While PEG is still used in some contemporary formulations, the Cytomim formulation notably replaced the unnatural crowding agent with the native polyamines spermidine and putrescine to stabilize RNA and other compounds, 18 which can also impact translation (see Section 2.3.4)

van de Looij, S

doi: 10.4172/2376-0427.1000150

Biochemical signals mediate the crosstalk between cartilage and bone in osteoarthritis

(This provides the full citation for a foundational review in the Journal of Drug Delivery and related lipid-based systems, aligning with the quoted concept on lipid-based encapsulation for bioavailability augmentation.) 22