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Mice exposed to cuprizone displayed a marked upregulation of HO-1 (p = 0.0008) that was partially reversed following toxin withdrawal, suggesting a dynamic regulation in response to redox imbalance

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[2] Functions [edit] This vitamer, along with adenosylcobalamin, is one of two active coenzymes used by vitamin B 12 -dependent enzymes and is the specific vitamin B 12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase