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Reduced apoptosis of neurons treated with acetyl-l-carnitine in nerve regeneration studies was confirmed by a recent systematic review [17]

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We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]

L-carnitine infusion also relieved the sensation of hunger and fatigue during the modified fasting period