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In the EAE model, elevated iron levels, lipid peroxidation, and mitochondrial morphological changes were observed in the spinal cord tissue of EAE mice, indicating the presence of classical biochemical alterations and pathological features of ferroptosis

Circulation 103 : 10061011 Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, Smith RS, Bottiglieri T, Bagley P, Selhub J, Rudnicki MA, James SJ and Rozen R (2001) Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

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The resulting oxidative stress promotes DNA breaks and upregulates PARP-1 expression (27)

Tew, K.D., and Woolley, P.V.), Chap