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Chiou WF, Lin LC, Chen CF (2004) Acteoside protects endothelial cells against free radical-induced oxidative stress

Discovery of human zinc deficiency: its impact on human health and disease

They discovered that using modified nucleotides (m 5 C, m 6 A, m 5 U, s 2 U or pseudouridine) in IVT mRNA, ablates the activation of TLR3, TLR7, TLR8 and TLR9 leading to a significant reduction in the production of type I interferons (IFNs) and pro-inflammatory cytokines compared to unmodified IVT mRNA (Figure 3) [ / ) MEFs, the extent of translation of -modified mRNA was not different from that of unmodified mRNA

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