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B., and Shang, X

This rapid clearance profile contributes to its exceptionally high safety margin and makes it highly suitable for daily, or even multi-dose, supplementation protocols

hence why it is atypical for someone to continue growing taller after their growth plates close

An imbalance of cholesterol transport is observed in individuals with high TMAO, and studies show that mice with administered TMAO inhibited the synthesis of hepatic bile acid by downregulating the expression of Cyp7a1, which promoted atherosclerosis [109]

Data availability The authors declare that the data generated in this study are provided in the Supplementary Information and Source Data file