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Dysregulation of one or more of these processes can result in inflammation-associated diseases [5, 6]

Drug, Healthcare and Patient Safety 13:8194 Torres J, Bonovas S, Doherty G, Kucharzik T, Gisbert JP, Raine T, Adamina M, Armuzzi A, Bachmann O, Bager P (2020) ECCO guidelines on therapeutics in Crohns disease: medical treatment

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Protein sequences were aligned using MUSCLE, and a phylogeny was estimated from the concatenated alignments using RAxML v7.7.8 50 with model PROTCATWAG with a total of 1,000 bootstrap replicates

Together, these mechanisms highlight the intricate cross-talk between IL-2 signaling, cell cycle machinery and metabolic priming, which jointly may contribute to the enhanced proliferative capacity of CD8 + T cells following transient cell cycle arrest