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In a previous Phase I trial, six patients treated with a single dose of NTLA-2001 showed significant reductions in serum TTR protein levels, with no serious adverse effects or liver damage reported

The results indicated an increase in both situations [14]

IJMS 22:11663

(488) revealed a notable reduction in cell viability corresponding to elevated dosages of polyphenols derived from Hippophae rhamnoides labeled as HPs60, showing an inactivation impact of HPs60 on tumor cell proliferation

For the targeted sulfur metabolite quantification approach, the previously established LC-MS conditions were applied 99 with selected reaction monitoring (MRM) using an Ultimate 3000 UPLC system coupled to a Thermo Finnigan TSQ Quantum equipped with HESI (Thermo Fisher Scientific, Waltham, MA)