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Our APAP program allows us to investigate the consequences of different dosing protocols of NAC on the recovery of GSH after an APAP overdose [10]

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The model predicts that initial knock-down of Keap1 by siKEAP1 is counteracted by increasing Nrf2 concentrations, which subsequently upregulate Keap1 and Srxn1 mRNA production (Fig 3C)

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