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NSAIDs are a common cause of gastric ulcers and intestinal lesions due to their inhibition of prostaglandin synthesis, which is crucial for mucosal defense

Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice

The researchers noted that people with long-standing drug addiction might not respond as well to the treatment

The assumption that more frequent equals more effective doesn't hold for compounds where the therapeutic mechanism involves triggered structural changes rather than sustained receptor occupancy

2013 Jun 10;184:1-5