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J Thorac Dis 12(3):329-337, 2020

Biochemical changes in intervertebral disc degeneration

Additionally, SDF-1 inhibits GSK3 activation by binding to the specific receptor CXCR4 and activating the PI3K-Akt pathway, thereby enhancing -catenin gene expression and facilitating the recruitment of MSCs and endothelial progenitor cells to injury sites [70]