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Studies have shown that anterograde synaptic transmission can modulate synaptic transmission and stabilize inhibitory synapses by activating postsynaptic receptors (e.g., GABA receptors), thereby influencing the excitatory-inhibitory balance in neural circuits (72)

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By blocking the breakdown of dopamine, selegiline helps compensate for the diminished production of dopamine in Parkinson's disease

Participants needed stable medication for over 3 months, effective Levodopa treatment, a stable condition, no contraindications to surgery or anesthesia, and no MRI abnormalities