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Limitations of Use: Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy [see WARNINGS], reserve opioid analgesics, including oxycodone and acetaminophen tablets, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain

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Potential weaknesses of our study include: the not yet delineated mechanism by which parkin regulates GR enzyme activity (as discussed above)

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(ii) Assessing colloidal stability over time under biologically relevant conditions (e.g., in PBS, cell culture media)