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On the supportive side, the foundational cell-culture work reported that the distinct E-domain of MGF inhibits terminal differentiation of myoblasts while increasing their proliferation a behavior opposite to that of mature IGF-1, and one that would fit the proposed role of expanding the precursor pool before differentiation

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Moreover, the absence of significant redox fluctuations does not necessarily disprove the hypothesis that cell cycle progression is accompanied by shifts in nuclear GSH concentration [44,45] because the total concentration of GSH could change without altering its redox potential

OCM for the male In Figure 1, substrates are in boxes and enzyme abbreviations in blue and yellow ovals