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In many neurological diseases, comprising both neurodegenerative and neurodevelopmental disorders, alterations in DNA methylation occur at specific genomic regions, including gene promoters, enhancers and CpG islands (25)

9 Impact of environmental factors on AA development Environmental factors, as in many other diseases, are considered significant contributors to both the onset and exacerbation of AA

PFK-deficient red blood cells display a metabolic block at the PFK step in glycolysis and have decreased concentrations of 2,3-bisphosphoglyceric acid (2,3-BPG, also called 2,3-diphosphoglyceric acid, 2,3-DPG

In recent years, rapid advancements in ferroptosis research have led to the discovery of many effective ferroptosis regulators for clinical applications, and these discoveries have opened new avenues for treating ferroptosis-related diseases, with some showing promising clinical prospects