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Key clinical characteristics of T2-low asthma include: Increased frequency among elderly patients who develop asthma later in life 16,20 Resistance to standard medications, particularly corticosteroids 12,15,21 A tendency toward asthma flare-ups and more serious disease manifestations 13,22 Diminished effectiveness of bronchodilators, as shown by lower forced expiratory volume measurements (FEV1%) 12 Airway obstruction and air confinement, measured by forced vital capacity (FVC%) 12 Increased functional residual capacity (FRC) 12 Greater need for steroids delivered through inhalers and orally to manage symptoms effectively

Cecal mass did not significantly differ between groups (Supplementary Table S2)

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C.PascarellaR.et al

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