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Suggested Use: 2-4 capsules per day or as recommended by your health care professional

Abbreviations 6-OHDA: 6-hydroxydopamine ATF: Activation transcription factor CCCP: Carbonyl cyanide-m-chlorophenylhydrazone CHOP: C/EBP homologous protein DA: Dopamine DAQ: DA-quinone DOPAC: 3,4-dihydroxyphenylacetic acid DOPAL: 3,4-dihydroxyphenylacetaldehyde ER: Endoplasmic reticulum GSH: Glutathione iPSC: Induced pluripotent stem cell IRE1: Inositol-requiring enzyme 1 L-DOPA: L-3,4-dihydroxyphenylalanine LRRK2: Leucine-rich repeat kinase 2 MAM: Mitochondrial-associated membrane MAO-B: Monoamine oxidase B MCU: Mitochondrial calcium uniporter MEF2C: Myocyte-specific enhancer factor 2C MPP + : 1-methyl-4-phenylpyridinium MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrabydropyridine mtDNA: Mitochondrial DNA NADH: Nicotinamide adenine dinucleotide PERK: Pancreatic ER kinase-like ER kinase PD: Parkinsons disease PGC-1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PINK1: PTEN induced putative kinase 1 ROS: Reactive oxygen species SN: Substantia nigra SNARE: Soluble N-ethylmaleimide-sensitive factor attachment protein receptor SOD: Superoxide dismutase TH: Tyrosine hydroxylase TOM: Translocase of the outer membrane UPR: Unfolded protein response UPS: Ubiquitin-proteasome system VMAT2: Vesicular monoamine transporter 2 VTA: Ventral tegmental area WT: Wild type XBP1: X-box binding protein 1 References Bellucci A, Mercuri NB, Venneri A, Faustini G, Longhena F, Pizzi M, et al

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The oxidative phase is also prevented from taking place and therefore NADPH is not produced

The Bioprotective Effects of Polyphenols on Metabolic Syndrome against Oxidative Stress: Evidences and Perspectives