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Inhibiting mitochondrial pyruvate import impedes the development of myofibroblasts [188,189]

Thats the compensation: an alternate drain the cell can open to offset what you did by inhibiting NNMT, which is part of why nonstop inhibition doesnt necessarily keep delivering the same clean effect forever

Depending on your goals, there are alternative ingredients that may deliver more noticeable results

doi: 10.1073/pnas.2317596121

Additionally, the treatment altered the levels of certain important molecules within the cells, suggesting changes that could inhibit cancer progression