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this reduces the enzymatic activity of MTHFR by approximately 35% per T allele , resulting in inefficient production of methylfolate ( Figures 3 and 4)

Activation of nuclear transcription factor PPAR-gamma by the novel triterpenoid CDDO as targeted therapy in breast cancer:158, 2002

Consequently, the mechanism of GLS1 action is more clearly defined, and the targeted inhibition of GLS1 has potential for use in cancer therapy

Ultrastructural analysis Graft samples were fixed in glutaraldehyde, dehydrated, impregnated, embedded in epoxy resin and acrylic, and cut into 60-nm sections using an ultramicrotome

doi: 10.1111/j.1572-0241.2007.01192.x 58