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Lin H, Huang H, Yu Y, Chen W, Zhang S, Zhang Y

Folic acid in combination with other vitamins, such as 400 mcg folic acid and 400 mcg vitamin B12 or 1,000 mcg of folic acid plus 7.2 mg vitamin B6 and 20 mcg vitamin B12, was also found to reduce homocysteine levels

To investigate LOD and LOQ of the analytes of interest, a proxy matrix (0.9% NaCl in 10 mmol/L phosphate buffer, pH 7.8) was spiked with decreasing concentrations of the standard solution of N-Hcy-Lys and low-molecular-mass thiols and subsequently subjected to all steps of the analytical procedure

several studies support a causal relationship between augmented NNMT activity in cancer cells and tumor proliferation/progression in a variety of cancerous states with potential implications for NNMT as a biomarker for cancer prognosis and a relevant target for anti-cancer therapeutic development