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In contrast to prior studies 9,12,14,15 , which primarily relied on baseline or intention-to-treatstyle exposure definitions, AHM exposure in the present study was measured throughout the follow-up, and participants with high exposure ( 80% PDC) of the medication class were grouped under the class and compared, an approach not utilised in previous studies 9,12,13,15,31

10.1161/CIRCULATIONAHA.122.058794 17 Feinberg AndrewP.AndreL

Importantly, no drug-related serious adverse events occurred across all studies

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Effluent water quality and ability to handle influent variability are the major reasons that many MBRs have been installed over the past 50 years