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For example, GSH-supported formation of Cu + or Fe 2+ can promote Fenton-like reactions that convert H 2 O 2 into highly reactive radicals, thereby damaging cellular macromolecules and promoting multiple forms of cell death 181,182

A lack of intracellular cysteine, GSH, or SLC7A11 suppression reduces GPX4 activity, which can enhance lipid peroxidation and trigger ferroptosis (47)

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In addition to long-range electrical and hydraulic signals, ROS waves and calcium are important components of systemic acquired acclimation during drought (Yoshida and Fernie, 2018)