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identified that low expression levels of ELOVL5 in breast cancer is correlated with poor prognosis because ELOVL5 can produce PUFAs that can induce ferroptosis in cancer cells [100]

In line with the importance of TXNRD1 in the regulation of ferroptosis and apoptosis in AML cells, auranofin, a TXNRD1 inhibitor, impaired cell viability in AML subtypes dependent on TXRND1 for their protection against ferroptosis [53]

Such changes remained in these same patients after 4 weeks of treatment (FENNS-4w) with the exception that the ratio of UA/Gr was completely normalized

Design of polyphenol-rich diets in clinical trials: a systematic review