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provided evidence that the interplay between the signals of mechanistic target of rapamycin kinase (mTOR) and GPX4 modulates autophagydependent ferroptosis in human pancreatic cancer cells, and the downregulated expression of GPX4 enhances the anti-cancer activity of rapamycin in vitro or in vivo by promoting ferroptosis and suppressing autophagy [38]

Finkelstein JD, Harris BJ, Martin JJ: Methionine metabolism in mammals: Concentrations of metabolites in rat tissues

However, the regulation of cholesterol accumulation in hepatocytes during NASH is not completely understood

doi: 10.1016/S0014-5793(00)01731-2 64

This downregulation subsequently inhibits NLRP3 inflammasome activation, leading to upregulation of GPX4/SLC7A11 or downregulation of ACSL4/ALOX15, and ultimately suppressing both ferroptosis and neuroinflammation