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These neuropathic symptoms can sometimes be misinterpreted as joint pain, particularly when affecting the hands, wrists, knees, or ankles

Falagas ME et al., Crit Care

Spiegel R, Kalla R, Mantokoudis G, Maire R, Mueller H, Hoerr R, Ihl R

Gelb, BD, Adams, V, Jones, SN, Griffin, LD, MacGregor, GR and McCabe, ERB (1992) Mitochondrial targeting of hexokinase in tumor cells

They used three different mice models, the maximal electrical shock (MES) model of epilepsy, ionized (INH) induced model, and pentylenetetrazol (PTZ) model, and evaluated the effect of the stem bark extract against various parameters such as seizure onset time, duration of convulsions, as well as estimated the level of GABA in the brain using two different doses of 250 and 500 mg/kg and compared with the standard AEDs diazepam