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For instance, because of its role in DNA repair, it is essential for cell division and plays a significant role in the formation and repair of all cells

This is precisely why demonstrating enzyme inhibition in a cuvette, or even in cultured melanocytes, does not translate automatically into a visible clinical result and why the human trials, rather than the mechanistic studies, have to carry the weight of any honest claim

Rascon-Aguilar IE, Pamer M, Wludyka P, Cury J, Vega KJ

Human evidence was available for a small number of parent phytochemicals and was rarely specific to nanoformulated products, while the majority of nanoformulation studies were preclinical and employed rodent or cell-line models

AG was used as a positive control