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Chast pervaya (Manual on Preclinical Studies of Drugs

321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury

M., Kasemo, B

Andrade, K

The addition of honey, however, promotes the conversion of DDAs to MDAs while inhibiting their further hydrolysis to NDAs, thus effectively lowering the DDA content while maintaining MDA levels in Aconiti Radix (Chuanwu)