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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective NNMT inhibitor that boosts NAD+ levels, enhancing mitochondrial function and fat oxidation

additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81

Higher doses may increase gastrointestinal side effects without improving outcomes