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The residual cells were arrested at the G0/G1 phase of the cell cycle, and the percentage of cells in the S phase was reduced, while the parental and regrown cells showed the similar cell cycle distribution

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Sigma) or vehicle for 30 min at 37 C before stimulation with the formylated peptide fMLF (Sigma)

High grade GI irAEs can result in serious morbidity and require endoscopy with biopsy, corticosteroid use and potential hospitalization