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Exp Physiol 105:15981609

doi: 10.1007/s10534-017-0037-7 27 OrenYTsabarMCuocoMSAmir-ZilbersteinLCabanosHFHtterJCet al

Overexpressing CircLRFN5 in glioblastoma has been demonstrated to mediate paired related homeobox 2 (PRRX2) protein degradation via the ubiquitin-proteasomal pathway, which transcriptionally downregulates GCH1-BH4 in GSCs and provokes ferroptosis[134]