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Discussion High Pyroglutamic acid indicates a disturbed GSH homeostasis in symptomatic TTR-V30M gene carriers In a recent study, we demonstrated that the formation of the aggregation-prone NNTTR species, initially discovered in plasma from TTR-V30M gene carriers [21], is promoted by the formation of a disulfide bridge [22]

Pre-digestion samples along with digested samples were run on SDS-PAGE and stained to verify digestion efficiency

HGF hepatocyte growth factor c-Met its type I tyrosine kinase-receptor HGF neuroprotective effect of the HGF on the nigrostriatal pathway, however, should be no surprise given its recognized role in stem cell regulation, the development of tubular structures (Santos et al., 1993) and its general proliferative, anti-apoptotic, motogenic, and morphogenic actions on many cell types including hepatocytes and cells of epithelial origin (Gherardi et al., 1993)

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