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50 U, S8160, Sigma-Aldrich) and catalase (2,000 U, C9322, Sigma-Aldrich) to eliminate extracellularly released O 2 and H 2 O 2

Research in Cellular Biology: It is extensively used in laboratory studies to investigate cellular processes, particularly in understanding the mechanisms of aging and disease

This leads to regions of tumors that are hypoxic, and, in turn, to regions where the extracellular pH is relatively low because of the production of lactic acid, and to poor clearance of this and other acidic products of metabolism (see Fig

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Biselli JM, de Angelo Calsaverini Leal RC, Ruiz MT, Goloni-Bertollo EM, Manglia JV, Rossit AR, et al