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Network medicine framework reveals generic herb-symptom effectiveness of traditional Chinese medicine

Li M, Yao D, Zeng X, Kasakovski D, Zhang Y, Chen S, et al

Bypassing liver metabolism means that when the product is taken, it goes directly into your bloodstream after absorption in the mouth, rather than going through the digestive system and liver first

(5)Fmoc-Asp(otBu)-Ala-Gly-Leu-Val- (5) Preparation of Fmoc-Asp(otBu)-Ala-Gly-Leu-Val-resin: (4)Fmoc-Ala-Gly-Leu-Val-1050530105010603DMF3DMF2DMFFmoc-Asp(otBu)-OHDIEATBTU/HOBtHBTU/HOBtBOP/HOBt105010603DMF3DMF2Fmoc-Asp(otBu)-Ala-Gly-Leu-Val- In the Fmoc-Ala-Gly-Leu-Val-resin in step (4), add the decapping reagent at 10-50C and react for 5-30 minutes, dry it with a vacuum pump, and add the decapping reagent again at 10-50C for 10-60 minutes , drained, washed 3 times with isopropanol, 3 times with DMF, 2 times with re-distilled DMF, added Fmoc-Asp(otBu)-OH, DIEA, TBTU/HOBt or HBTU/HOBt dissolved in DMF or The mixture of BOP/HOBt was reacted at 10-50C for 10-60 minutes, dried by vacuum pump, washed 3 times with isopropanol, washed 3 times with DMF, washed 2 times with re-distilled DMF, and dried to obtain Fmoc-Asp (otBu)-Ala-Gly-Leu-Val-resin