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Cystinosin deficiency leads to impaired lysosomal clearance and disrupted endolysosomal trafficking, which in turn contributes to defective autophagy and altered proteostasis [144, 146, 147]

Glutamine is an important energy source for tumor cells, and metabolic reprogramming of glutamine signaling contributes to immune evasion in the tumor microenvironment via limiting immune cell glutamine utilization and regulating tumor PD-L1 expression ( There is also emerging evidence for the role of asparagine and asparagine synthetase (ASNS) in immune activation in lung cancer

Melatonin provides protection against cisplatin-induced ovarian damage and loss of fertility in mice

Yes, when administered at proper doses under medical supervision