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TT and RBG are supported by the Austrian Science Fund (FWF, SFB Lipid hydrolysis (F73), DK-MCD (W1226)

Therefore, the relatively low abundance of lipoylation in untreated cells suggests that lipoylation is rate-limiting for the OGDHc, and our findings are consistent with the accumulation of Lp glu following ABHD11 inhibition, which reduces OGDHc activity (Fig

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89 Resistance due to Inactivation by Glutathione or GSTs Intracellular inactivation of alkylating agents has been implicated in human tumor resistance

For example, p53 depletion can enhance cell proliferation and survival, disrupt apoptosis and increase genomic instability by altering the expression of REDD1, an mTOR suppressor